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Hello Im Positive Thinking Person All The Time - Sometime
Question: hello
Im positive thinking person all the time - sometime when you start reading literature it makes you worry about your family !
But its important to think positive - im sure you gone help me in positive maner with positive answer
I have questing about Glomerulonephritis
As from literature what i read acute Glomerulonephritis is rare in the world - maybe some case are not reported but still rather rare 1.7 - 100 000
Very good article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC0000/#appsec1
And as from acute Glomerulonephritis most common cause agent is streptococcal infection
And other agents rare cause acute Glomerulonephritis
Here is article about other agents
https://emedicine.medscape.com/article/239278-overview#showall
But as such bacteria and viruss like Staphylococci and Epstein-Barr virus is common in population affecting more than 90 % of population but cases of acute Glomerulonephritis very rare - and from literature and my conclusion other pathogens than streptococcal very rare cause acute Glomerulonephritis
And as acute acute Glomerulonephritis can also lead to Chronic Glomerulonephritis
But its overall prevalence of Chronic Glomerulonephritis is rather rare in all population -
https://emedicine.medscape.com/article/239392-overview#showall
As i understand it is important to treat such infection like - malaria, schistasoma, C hepatitis - so they dont cause cause problem of Glomerulonephritis
So in conclusion - keep healthy, exercise, and dont stress as
AS everythin will be OK
Is it so doctors
thank you for positive answer
Im positive thinking person all the time - sometime when you start reading literature it makes you worry about your family !
But its important to think positive - im sure you gone help me in positive maner with positive answer
I have questing about Glomerulonephritis
As from literature what i read acute Glomerulonephritis is rare in the world - maybe some case are not reported but still rather rare 1.7 - 100 000
Very good article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC0000/#appsec1
And as from acute Glomerulonephritis most common cause agent is streptococcal infection
And other agents rare cause acute Glomerulonephritis
Here is article about other agents
https://emedicine.medscape.com/article/239278-overview#showall
But as such bacteria and viruss like Staphylococci and Epstein-Barr virus is common in population affecting more than 90 % of population but cases of acute Glomerulonephritis very rare - and from literature and my conclusion other pathogens than streptococcal very rare cause acute Glomerulonephritis
And as acute acute Glomerulonephritis can also lead to Chronic Glomerulonephritis
But its overall prevalence of Chronic Glomerulonephritis is rather rare in all population -
https://emedicine.medscape.com/article/239392-overview#showall
As i understand it is important to treat such infection like - malaria, schistasoma, C hepatitis - so they dont cause cause problem of Glomerulonephritis
So in conclusion - keep healthy, exercise, and dont stress as
AS everythin will be OK
Is it so doctors
thank you for positive answer
Brief Answer:
There are many causes of glomerulonephritis, but generally it is rare
Detailed Answer:
Hello, I'm Dr. Branch, thanks for using 'Ask a Doctor'. As the articles you mention point out, there are many causes of glomerulonephritis, and classifying glomerulonephritis into acute and chronic categories can be somewhat arbitrary since almost all the causes can cause both. As the article states, post-streptococcal glomerulonephritis (PSGN) is well known and studied, but because of the more frequent use of antibiotics for strep infections, it is relatively rare these days. Internationally, IgA nephropathy is the most common, and I personally see mostly cases of autoimmune glomerulonephritis such as with lupus.
Usually a patient with glomerulonephritis will have noticeable symptoms, such as dark urine, less urine output than normal, and possibly swelling, especially in the legs. The blood pressure can also go up which can be detected when checking the blood pressure. The condition can be easily seen on a urinalysis. A patient may also have other symptoms, such as joint pain or rash.
So it is true that relatively speaking glomerulonephritis is rare, and usually will have other symptoms that will help detect it, so I wouldn't say that people need to check for it without any symptoms or be concerned about it. I would just recommend as you said, keep healthy, exercise, regularly see your doctor at least once a year, and I don't think there would be anything to worry about.
I hope that helps, please let me know if you have any other questions about that, and I would be glad to discuss it with you further.
There are many causes of glomerulonephritis, but generally it is rare
Detailed Answer:
Hello, I'm Dr. Branch, thanks for using 'Ask a Doctor'. As the articles you mention point out, there are many causes of glomerulonephritis, and classifying glomerulonephritis into acute and chronic categories can be somewhat arbitrary since almost all the causes can cause both. As the article states, post-streptococcal glomerulonephritis (PSGN) is well known and studied, but because of the more frequent use of antibiotics for strep infections, it is relatively rare these days. Internationally, IgA nephropathy is the most common, and I personally see mostly cases of autoimmune glomerulonephritis such as with lupus.
Usually a patient with glomerulonephritis will have noticeable symptoms, such as dark urine, less urine output than normal, and possibly swelling, especially in the legs. The blood pressure can also go up which can be detected when checking the blood pressure. The condition can be easily seen on a urinalysis. A patient may also have other symptoms, such as joint pain or rash.
So it is true that relatively speaking glomerulonephritis is rare, and usually will have other symptoms that will help detect it, so I wouldn't say that people need to check for it without any symptoms or be concerned about it. I would just recommend as you said, keep healthy, exercise, regularly see your doctor at least once a year, and I don't think there would be anything to worry about.
I hope that helps, please let me know if you have any other questions about that, and I would be glad to discuss it with you further.
Above answer was peer-reviewed by :
Dr. Saisudha Kotla
Hello Thank you very much for your answer !
So in Conclusion
1. Disease like C hepatitis, and B hepatitis don cause acute glomerulonephritis
Acute hepatitis B virus (HBV) infection has very rarely been associated with glomerulonephritis.
https://pubmed.ncbi.nlm.nih.gov/0000/
And i did not find any evidence that acute C hepatitis cause acute
I know that chronic C hepatitis can cause glomerulonephritis but treatment in time avoide this problem
So in coulcusiosn - acute C and B hepatitis does not cause glomerulonephritis
2. question
IgA Nephropathy - is rare disease in all litereature it is said and also statistic prove that
The estimated annual incidence in Japan is 3.9–4.5 per 100,000 population
https://emedicine.medscape.com/article/239927-overview
of US studies calculated an annual incidence of 1.29/100 000 people
https://pubmed.ncbi.nlm.nih.gov/0000/
But some article said that
IgAN, which was not previously recognized to be an inherited disorder, affects up to one percent of the population worldwide
https://www.hhmi.org/news/common-kidney-disease-has-genetic-basis
. IgA nephropathy (IgAN) is the most common form of glomerulonephritis, a principal cause of ESRD worldwide, affecting up to 1.3% of the population.
https://www.omim.org/entry/161950
I think it is huge mistake - sometimes this article dont understand what they are writing - for exaple if there would be 1 % of population with IgA nephropathy then we would have so much end stage kidney disease
if it would be could see a lot of end stage kidney disease - but we dont
And all publication say it is rare disease -
So in conclusion IgA nephropathy much less than 1 % in population
Thank you very much
So in Conclusion
1. Disease like C hepatitis, and B hepatitis don cause acute glomerulonephritis
Acute hepatitis B virus (HBV) infection has very rarely been associated with glomerulonephritis.
https://pubmed.ncbi.nlm.nih.gov/0000/
And i did not find any evidence that acute C hepatitis cause acute
I know that chronic C hepatitis can cause glomerulonephritis but treatment in time avoide this problem
So in coulcusiosn - acute C and B hepatitis does not cause glomerulonephritis
2. question
IgA Nephropathy - is rare disease in all litereature it is said and also statistic prove that
The estimated annual incidence in Japan is 3.9–4.5 per 100,000 population
https://emedicine.medscape.com/article/239927-overview
of US studies calculated an annual incidence of 1.29/100 000 people
https://pubmed.ncbi.nlm.nih.gov/0000/
But some article said that
IgAN, which was not previously recognized to be an inherited disorder, affects up to one percent of the population worldwide
https://www.hhmi.org/news/common-kidney-disease-has-genetic-basis
. IgA nephropathy (IgAN) is the most common form of glomerulonephritis, a principal cause of ESRD worldwide, affecting up to 1.3% of the population.
https://www.omim.org/entry/161950
I think it is huge mistake - sometimes this article dont understand what they are writing - for exaple if there would be 1 % of population with IgA nephropathy then we would have so much end stage kidney disease
if it would be could see a lot of end stage kidney disease - but we dont
And all publication say it is rare disease -
So in conclusion IgA nephropathy much less than 1 % in population
Thank you very much
Brief Answer:
Hepatitis B and C can cause glomerulonephritis
Detailed Answer:
Hello again, thanks for the follow up question.
1. Just to clarify, hepatitis B and C can cause glomerulonephritis, I wouldn't say it is very common, but it is not rare either for those who have those diseases. I have personally seen many patients with hepatitis B who also get glomerulonephritis, because I see many patients with hepatitis B.
2. IgA nephropathy that causes any noticeable kidney damage is certainly less common than 1%. I believe the article that you cited was saying that up to 1% of the population have the gene that can lead to IgA nephropathy, but I think the article is not careful to say that not everyone who has the gene gets IgA nephropathy, it just makes them more susceptible. Also, it's important to point out that many people get IgA nephropathy, but it doesn't cause end-stage renal disease (ESRD), and may not even be noticed by the patient, as it can resolve on its own and not leave any permanent damage.
Please let me know if you have any other questions, I'd be glad to help any way I can.
Hepatitis B and C can cause glomerulonephritis
Detailed Answer:
Hello again, thanks for the follow up question.
1. Just to clarify, hepatitis B and C can cause glomerulonephritis, I wouldn't say it is very common, but it is not rare either for those who have those diseases. I have personally seen many patients with hepatitis B who also get glomerulonephritis, because I see many patients with hepatitis B.
2. IgA nephropathy that causes any noticeable kidney damage is certainly less common than 1%. I believe the article that you cited was saying that up to 1% of the population have the gene that can lead to IgA nephropathy, but I think the article is not careful to say that not everyone who has the gene gets IgA nephropathy, it just makes them more susceptible. Also, it's important to point out that many people get IgA nephropathy, but it doesn't cause end-stage renal disease (ESRD), and may not even be noticed by the patient, as it can resolve on its own and not leave any permanent damage.
Please let me know if you have any other questions, I'd be glad to help any way I can.
Above answer was peer-reviewed by :
Dr. Saisudha Kotla
Thak you for great answer !
1. Yes i know that b and c hepatitis can cause
glomerulonephritis but it is when they are in chronic stage ! As all literature has described that !
So acute or chronic glomerulonephritis develop in disesa c and b hepatitis chronic stage !
Thats why literature say that it is important to treat c hepatitis in early stage before problems !
And get b hepatis vaccine !
What i say that glomerulonephritis wont develop right after infection c and b hepatitis it takes time in chronic stage to develop !
2. Yes you are rigt - it is said about IGAN1 gene
But if you have this gene it does no mean that you gone develop disease as there are lot of genes that put togeher there is not prove that one gene is releted to this disease !
So having this gene it is unlikley to cause IgA nephropathy as there are complex of genes from wich we dont konow lot of theme....
As literature explain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC0000/
Although the large linkage studies have yielded genetic signals at 6q22-23 (locus named IgAN1),21 4q26-31 (locus named IgAN2),22 17q12-22 (locus named IgAN3),22 and 2q3623 for familial IgAN. Using a large Lebanese-Druze kindred (5 generations and 16 affected individuals), Karnib et al.24 found no evidence of linkage to the known IgAN loci on chromosomes 6q22-23, 2q36, and 4q22-31. Furthermore, no likely candidate genes in these loci have yet to be identified (Supplementary Table S1). The elusive results of linkage studies indicate the complex genetic background of IgAN, and for complex trait conditions, such as IgAN, accuracy in classifying affected and unaffected individuals is crucial.
Than you very much !
1. Yes i know that b and c hepatitis can cause
glomerulonephritis but it is when they are in chronic stage ! As all literature has described that !
So acute or chronic glomerulonephritis develop in disesa c and b hepatitis chronic stage !
Thats why literature say that it is important to treat c hepatitis in early stage before problems !
And get b hepatis vaccine !
What i say that glomerulonephritis wont develop right after infection c and b hepatitis it takes time in chronic stage to develop !
2. Yes you are rigt - it is said about IGAN1 gene
But if you have this gene it does no mean that you gone develop disease as there are lot of genes that put togeher there is not prove that one gene is releted to this disease !
So having this gene it is unlikley to cause IgA nephropathy as there are complex of genes from wich we dont konow lot of theme....
As literature explain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC0000/
Although the large linkage studies have yielded genetic signals at 6q22-23 (locus named IgAN1),21 4q26-31 (locus named IgAN2),22 17q12-22 (locus named IgAN3),22 and 2q3623 for familial IgAN. Using a large Lebanese-Druze kindred (5 generations and 16 affected individuals), Karnib et al.24 found no evidence of linkage to the known IgAN loci on chromosomes 6q22-23, 2q36, and 4q22-31. Furthermore, no likely candidate genes in these loci have yet to be identified (Supplementary Table S1). The elusive results of linkage studies indicate the complex genetic background of IgAN, and for complex trait conditions, such as IgAN, accuracy in classifying affected and unaffected individuals is crucial.
Than you very much !
Brief Answer:
Yes, usually hepatitis B and C are chronic diseases
Detailed Answer:
1. Yes, that is true, it is typically when they are chronic diseases, but most of the time when we see hepatitis B and C, they are chronic diseases.
2. Yes, that is correct. The disease probably has many different factors that cause it, including genetic and environmental factors.
Please let me know if you have any other questions, I'd be glad to help any way I can.
Yes, usually hepatitis B and C are chronic diseases
Detailed Answer:
1. Yes, that is true, it is typically when they are chronic diseases, but most of the time when we see hepatitis B and C, they are chronic diseases.
2. Yes, that is correct. The disease probably has many different factors that cause it, including genetic and environmental factors.
Please let me know if you have any other questions, I'd be glad to help any way I can.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by :
Dr. Saisudha Kotla
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