Ok, here I go! Six months ago I was put on sollupred 5 mg per day and ursofalk 250 mg 2 then 3 capsules per day for treatment or rather protection from PBC complications. I was also given zyloric 100mg for gout or elevated uric acid. I was also taking legalon 280 mg per day then changed into milk thistle 250 mg. There was also vitmin E 800 units and osteocare (calcium plus magnesium plus zinc) once daily.At first, I felt great, but gradually I started going down the hill again; I was back to my fatigue fits. Things got worse when I started seeing an endocrinologist for my slightly hypo with presence of nodules thyroid and only a month ago I was put on eltroxin 50mg. I believe I was sliding into depression then I started doubting drug interaction.I am now gradually withdrawing from the sollupred (prednisone) and am reducing the ursofalk into once daily instead of three. I stopped the zyloric and the osteocare. Since I am disobeying my doctor, I was wondering if I am putting myself at risk? I am also wondering if I can take the sollupred at night time during withdrawal? Thank you, and please note that I am feeling much better emotionally and slightly better physically since I started monitoring my medication intake. I just hope it is not a false sensation!