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What Causes Elevated Bilirubin Levels In A Colon Cancer Patient?

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Posted on Fri, 21 Aug 2015
Twitter Fri, 21 Aug 2015 Answered on
Twitter Mon, 14 Sep 2015 Last reviewed on
Question : Metastic colon cancer - what can it mean if bilirubin has increased significantly? Mets fo liver and peritonium
doctor
Answered by Dr. Shoaib Khan (37 minutes later)
Brief Answer:
If liver met confirmed, then rise in bilirubin marks gradual deterioration

Detailed Answer:
Hello and welcome.

Thank you for writing to us.

I have gone through your query with diligence and would like you to know that I am here to help. If you do not mind, please clarify whether the spoken person has been confirmed to have metastasis to his liver and peritoneum?

If this is the case, then the rise of bilirubin marks gradual deterioration of the health of the liver unfortunately. If the liver metastasis has been confirmed, then the liver's health will only worsen.

I hope you find my response helpful. Please feel free to write back to me for any further clarifications, I would be more than happy to help.

Best wishes.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shoaib Khan (7 hours later)
Yes liver metsstases is confirmed. Threre was a 7 cm met which on chemo in 3 months gone to 8 cm, there is a 6 cm met and a 4 cm met.

The chemo has got rid of the 3 small 1cm mets in liver and scan reveals no further mets in
Body but the larger ones have still grew. And bilirubin rising?

How do these damage the liver? For 8,9 montgs the bilirubin was always normal.

Can the chemo have damaged the liver or the cancer ?

Ther is fever to

o
doctor
Answered by Dr. Shoaib Khan (15 hours later)
Brief Answer:
If damage is due to chemo, it should return to normal

Detailed Answer:
Hi.

Thank you for that information.

The bilirubin rises when there is an abnormality in the liver either disease, syndrome or a growth (tumor or cancer). In this case, as cancer is confirmed the mets that are large must be continuing to grow in the liver causing its health to deteriorate. Bilirubin helps determine the health of the liver, and so as it seems to be rising off late it could be because the mets in the liver may be either increasing in size which must be further damaging the liver or the mets must be taking up all the nutrition resulting in damage to the liver.

I think the cancer is what is damaging the liver, and not the chemo; but chemo is also quite strong and could have caused some amount of damage to the liver also.

Best wishes.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shoaib Khan (11 hours later)
Plus appetite loss- not eating at all and mow weight is 42 kg and hes 67 year old male. Is this end stage?
doctor
Answered by Dr. Shoaib Khan (17 minutes later)
Brief Answer:
Quite possibly is :(

Detailed Answer:
Hello.

I am afraid it could be, depending on how many mets he has and how far the spread is, we can estimate his life expectancy (not more than a year I am guessing). I am sorry to be the one informing this to you.

Best wishes.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shoaib Khan (50 minutes later)
There are 3 in the liver all fairly big and 3 in petitoneal area?
doctor
Answered by Dr. Shoaib Khan (3 hours later)
Brief Answer:
Life expectancy is in majority of cases inaccurate

Detailed Answer:
Hi.

Not good for prognosis or life expectancy, I am afraid. A close relative of mine had 3 small ones spread to his lung, and if I had to go by textbook I would have to give him a 6-18 month life expectancy, which I did.

I had to then leave to go out of the country for a while (5 days), on the night of my return, before I boarded the flight I was informed about his demise.

So you see things are unpredictable, but based on the provided information I would say life expectancy is anywhere near 2 months to 8 months (approximately).

Best wishes.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shoaib Khan (28 minutes later)
I see. So what exact do the mets do to the liver ? Also chemo has got rid of the small 1 cm ones and cea dropped to but the big ones keep growing . Why is that ?
doctor
Answered by Dr. Shoaib Khan (5 hours later)
Brief Answer:
Explained sir

Detailed Answer:
Hi.

The mets take up all the space, leaving less of the healthy cells in the liver. The lesser the healthy cells, the lesser the percentage of function. Also the mets take up nutrition leaving lesser for the cells of the liver, and thus resulting in death of cells.

The bigger ones grow bigger because they have more and more nutrition for themselves, and in turn this spells bad news for the liver.

Best wishes.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shoaib Khan (1 hour later)
I see . So can a 7 cm met, 6 cm met n 4 cm met all in liver danage it this much thst bilirubin has shot up and fever and severe weight loss ?
doctor
Answered by Dr. Shoaib Khan (2 minutes later)
Brief Answer:
Even one of them is enough to cause a rise in bilirubin

Detailed Answer:
Yes it most certainly can sir.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shoaib Khan (2 minutes later)
Whst is option if chemo not helping ?
doctor
Answered by Dr. Shoaib Khan (9 minutes later)
Brief Answer:
Unfortunately no other option sir

Detailed Answer:
Hi.

If chemo is not helping, it means the cancer has reached a stage where options like surgery, chemotherapy, radiotherapy, etc; cannot be used anymore. In such cases we have to unfortunately just go about palliative therapy (treating the symptoms to make the individual more comfortable), because the main condition is beyond control and all we can do is to make the individual as comfortable as possible until the irrelevant death approaches.

Best wishes.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Shoaib Khan

General & Family Physician

Practicing since :2009

Answered : 9409 Questions

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What Causes Elevated Bilirubin Levels In A Colon Cancer Patient?

Brief Answer: If liver met confirmed, then rise in bilirubin marks gradual deterioration Detailed Answer: Hello and welcome. Thank you for writing to us. I have gone through your query with diligence and would like you to know that I am here to help. If you do not mind, please clarify whether the spoken person has been confirmed to have metastasis to his liver and peritoneum? If this is the case, then the rise of bilirubin marks gradual deterioration of the health of the liver unfortunately. If the liver metastasis has been confirmed, then the liver's health will only worsen. I hope you find my response helpful. Please feel free to write back to me for any further clarifications, I would be more than happy to help. Best wishes.