Does Chemotherapy For Lung Cancer Cause Constipation?

Sure, my wife has had one treatment of chemotherapy for lung cancer, and she is bound up. All the web site tells about is that one can become constipated due to the drugs, but no clue on how to start things moving again. It has been 4 days since her last bowel movement, and she is feeling uncomfortable to say the least. Is it OK to start an enema? She did insert a glycerine suppository a few hours ago, but so far, nada. Thanks, Bill Edmiston