Have IBS But Lately, It Is Continuous. I Have Nausea,

Have IBS but lately, it is continuous. I have nausea, diarrhea, cramping, fatigue and thirst. Have been on omeprazole which did nothing. Have tried one with itiza in the name. Sorry, forgot the name. Nothing helps. Could it be something else? Have always been a big salad, veggie, fruit eater. Big homemade popcorn eater. No butter . Very little meat. Not a vegan but just don't like the taste. Amount of daily exercise is average. Walk my dogs at least one mile each day and do other exercises at night.
Thank you