Hi, My Wife Has Been On Aranesp For Almost A

Hi, My wife has been on Aranesp for almost a year now for LGL. Her numbers at first were good. But recently her numbers have been going down. About a moth or so ago they dipped so low That she had to have an emergency transfusion. She is in constant pain. Abdominal pain, nausea, fatigue,sweats and chills, bone aches,can't sleep, shortness of breath,and a general feeling that she's going to die. Many doctors are working with her. But we are not far from where we started from last November. The Doctors seem at a loss as to what to do next. We are in one of the best cancer hospitals in the area. We don't now where to go from here. I don't want her to give up. Thank You for any professional insight.