I am 64, and had a hystorectomy when I was 20. I was on 1.25 premiren oral tablet, until 5 years ago and stopped suddenly myself. I then changed to a .1 transdermal patch, but it is nothing like the tablets. The tablets were wonderful for me with no side effects whatsoever except for feeling normal. The patch I now use has caused 3 size larger breasts, and a 20 pound weight gain, which is the opposite of the premiren I took all my life. I changed because I thought the patch is safer. My doctor said it was. But the effects are not safer, or comfortable and I want to return to 1.25 oral premiren as I took before. My doctor even said I was one of the few that had good results from them. The patch is miserable for me. I'm so fat I can't wear anything I own. I was size 4 all my entire life. Help, or suggestion. Excellent health except for this. Getting ready to stop patch, and get my old script going again. Had no problem with it.