I Am Having A Lot Of Night Time Pain In

I am having a lot of night time pain in my legs, also when I sit down, I get twinges(precursors to cramp). I am 55 years old, female, menopausal. I have cml, diabetes type 2, arthritis, and gout. I am 5'9, weight 118 kg. I am taking tasigna, Nexium, combiglitz , meloxicam, progout, zan extra, as well as magnesium, and Max gxl(nutritional supplement).
the pain is becoming more and more disabling. Please could I get some feedback on what I could do to ease this problem?