I am not sure connected, but...sore joints throughout body. Not enough to prevent function, but uncomfortable. I am typically irregular, but always gassy. Fiber daily, but rarely helps. Don't want to use laxatives and become dependent. Rare episodes of diarrhea and then back to constipation. I am hypothyroid, but current script has bloodwork stable and has been for some time. Been told clogged gall bladder, but nothing that has warranted surgery to remove. May just be getting old...to be 49 this Sept, but hating the belly fat gain and bloated feeling