I am on 200mg amiodorone 3/week, 81mg aspirin 1/d Lisinopril 1/day, 12.5 mg caray, 40mg crestor 1/day, 7.5mg warfarin 1/day, 5mgvedillol 2/day, zetia 1/day and I take vitamins and flax oil. I have a history of migraines. In addition I have an old neck injury from a car accident. This causes severe headaches as well. I have been taking fioricette 2 at a time and it helps a little. I am 62 years old, weigh 170, walk 4-5 miles/day, bike regularly, etc. My cousins wife has suffered from migraines for 35 years. A couple of years ago she tried taking edible forms of cannibus. It has helped her greatly. I looked up drug interactions and didn't find much of an interaction except with drugs that cause drowsiness. Have you found this to be effective for pain? I have been thinking of trying a small amount.