I Am Taking Quetiapine 50mg For Sleep. Also Bupropion Xl

I am taking Quetiapine 50mg for sleep. Also bupropion xl 150 mg per day and venlafaxine er 75 mg per day. For my blood pressure I take carvedilol 6.25mg at 2 per day and hydrochlorothiazide 25mg per day. Since the doctor added the bupropion on I have trouble with extreme tiredness. If I do any housework or yard work I feel terrible for several days. Also have an almost constant bad feeling in my bronchial area. What can I do about this? Would it be wise to try something else or try to go off the last med altogether? I am a highly sensitive person and have been through so many trying times in my life I am now on all these meds for my depression. Any suggestions?