I Am Very Concerned With My Sisters Health. She Has

I am very concerned with my sisters health. She has edema, psoriasis, joint pain, weight gain! She can't seem to loose weight no matter how hard she tries! She very rarely sweats when she exercises! Every test she takes comes back normal! Thyroid is normal! Blood pressure 110/68 p72! Doctors tell her everything is fine and she needs to diet and exercise! Her swelling is ridiculous! Please help! ! She is getting very depressed!