I have been on Tramadol, neuron tin, hormones (from a hysterectomy), Trintellix, and Klonopin for anxiety. I haven't takin Tramadol for over a week now. I do deal with chronic constipation, and have felt very bad the last few days. I did take a laxative (yesterday), have been drinking lots of water without success. I repeated the laxative, with my abdomen becoming uncomfortable and cramping. I used an enema which worked right away. I feel a little better but my stool was watery and dark looking. Charcoal like. Wondering i I should go to the ER. Should I be concerned?