I Started Compounded HRT On 8-20-2015. No Change With Symptoms!

I started compounded HRT on 8-20-2015. No change with symptoms! I take several supplements for RA. I am concerned that these are interfering with my HRT. I spoke with the pharmacist today. She advised me to stop supplements, such as, milk thistle, because they are metabolized in the liver. There are more that we are not sure about. Can you help with this? Thank You.