MY Husband Is A Diagnosed Heart Patient With A Dual

MY husband is a diagnosed heart patient with a dual chamber pacer and several mess recently have had symptoms of angioedema and difficulty breathing which requires inhaler or o2 use which is not the norm doctors are not listening to the angioedema part. I am concerned that we have a drug interaction problem going on He currently takes 25mg metoprolol daily 60mg lasik 100 mg amiodarone and 5mg warfarin.About 3 months ago lasik was upped to the 60 mg and this is when symptoms seemed to become apparent. Are any of these drugs a do not mix and can the increase in lasting bring about and underlying reaction to any of the other mess