Medications Whether They Be Oral, Cream, Or By A Shot

Medications whether they be oral, cream, or by a shot are constricting/tightening the torso part of my body. It is very serious and scary. It's like it is affecting muscles in my upper abdomen/chest area and my lower abdomen/pelvic area. As medication builds up in my system it can get to pulling and squeezing so tight that it gets to pulling into my back, my legs start feeling really funny and I can get real numb, tingly feeling. And sometimes when it is getting this bad, I'll start getting a real cold feeling, like the circulation is being cut off. Applied heat, like a very warm bath or shower, or a heating pad will cause tightening and will severely make a medication reaction worse. My body is accepting medications by IV so far. Haven't had a reaction by a certain medicine by IV yet. I don't understand. Have been to many doctor's and had many tests, including intestinal, cat scan and mri on abdomen/pelvic, emg, etc. I have degenerative disc disease and see a neurosurgeon and he claims nothing in my back is causing this. I have medical conditions that I need to be treating daily with medicine, but can't. I get scared about this problem and deal with a lot of pain and discomfort. Any medical suggestions of what could be going on with me? How can I resolve and treat my other medical conditions daily if this medicine reaction can't be resolved? Thanks.