Please Help... I'm 33 F And I Don't React To

Please help... I'm 33 F and I don't react to medications in a normal way. I can take a medication and within 2-3 days it has NO effect whatsoever. I'm not crazy, I've talked to other people with the same issue but no-one has a name for this. My Drs just keep trying more and more drugs and nothing helps for more than a few days. PLEASE has anyone head of this? (I have never abused ANY drug or substance)