HealthCareMagic is now Ask A Doctor - 24x7 | https://www.askadoctor24x7.com

Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
159 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction

Pulmonary Toxicity, Lung Cancer, Been Dehydrated. Been Taking Gemzar And Taxol. Taken Chest XRays. What Can Be Done?

My mother developed pulmonary toxicity after 3 rounds of Gemzar and Taxol. She is on a vapor o2 with at 25 liters with a FIO2 of 90 percent. She is getting decadron and vancomycin and azotrem. She desates to 76 with exertion. Chest xrays show no improvement after 5 days, she is in ICU. The pulmonologist want to decrease her decadron and move her to a step down. I asked where they saw improvement. The only answer I received is she is on a 90 fio2 instead of 100 percent. Respiratory treatment were not started until wed. She was admitted last Friday. Initially she was just treated with IVF and one antibiotic dose every 72 hours, as they thought she was just dehydrated. She started to crash on Monday at which time we were told she had pneumonia, not to worry. Finally a pulmonologist told us it was the pulmonary toxicity and not the typical pneumonia. Her BUN and Creatinine are good, so is her ejection fraction. The lung cancer is small at this time and would not cause any symptoms per the oncologist. I feel she has not had timely treatment and am concerned about the decrease in decadron without seeing improvement. I would like to get her to a university hospital and second opinion from a different pulmonologist
Mon, 30 Sep 2013
Report Abuse
Oncologist 's  Response
First treatment is the withdrawal of this drug. Some who develop paclitaxel induced lung toxicity respond fast to withdrawal of the drug.

The second choice of treatment is administration of corticosteroid. Usually
prednisolone at a dose of 30 to 60 mg per day is
given for 2 to 3 weeks, and higher doses like pulse
therapy are administered for more severe conditions
such as acute respiratory failure, with a slow and
careful tapering


Paclitaxel induced interstitial pneumonia usually responds rapidly to steroid therapy.

Regards and take care




I find this answer helpful

Note: For further queries related to kidney problems Click here.
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]
Share on
 

Related questions you may be interested in


Recent questions on Prednisolone


Loading Online Doctors....
Pulmonary Toxicity, Lung Cancer, Been Dehydrated. Been Taking Gemzar And Taxol. Taken Chest XRays. What Can Be Done?

First treatment is the withdrawal of this drug. Some who develop paclitaxel induced lung toxicity respond fast to withdrawal of the drug. The second choice of treatment is administration of corticosteroid. Usually prednisolone at a dose of 30 to 60 mg per day is given for 2 to 3 weeks, and higher doses like pulse therapy are administered for more severe conditions such as acute respiratory failure, with a slow and careful tapering Paclitaxel induced interstitial pneumonia usually responds rapidly to steroid therapy. Regards and take care