Suggest Medication For Swollen Big Toe

my wife has a swollen big toe... she's had it for 2 days now. very painful to the touch and when she tries to bend it... she started taking vitamin D prespription about 1 month ago because her level is abnormaly low. She is asian, in good shape, no excess weight and mid 30's. This is very concerning to me. I am wondering if this can be something serious... like something that we need to worry about this week-end or whether it can wait until next week. Any help would be appreciated.