Yes. My Left Ankle On The Top Hurts When I

Yes. My left ankle on the top hurts when I walk and when it bends. My right knee is also giving out on me when I go up the stairs. Between the two, I just am having trouble walking at work. I am 5'6" and have Hashimotos Thyroiditis. I have difficulty loosing weight. I use to be at 160. Now, I am at 220 and just hate the weight...mostly all in my stomach area. I feel like the weight is contributing to these ailments. I've always been active with walking and running. Now, I am loosing hope. Any ideas????