I Have Chronic Asthma, Been On Xolair, Nucala Now Fasenra

i have chronic asthma, been on xolair, nucala now fasenra injections, first two injection i became allergic, when i got my second shot of fasenra. it seems my body went down, headaches, flu like systems, itching, blood clots from my nose and my increased inr for no reason. only change was the fasenra injections, could this have affected the coumadin i take?