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Are Centramine, Entresto And Carvedilol Safe To Take Together?

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Posted on Tue, 8 Aug 2023
Question: Hi, I am currently taking Entresto 24/26mg twice daily, and carvedilol 18.5mg twice daily, as well, synthroid 88mg 1 x daily, and sertraline 25mg 1x daily. i desperately need to loose weight, and the clinic i have been referred to is suggesting i take centramine, appetite surpresant, and i am concerned about whether these will conflict.
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Answered by Dr. Dr. Michelle Gibson (18 minutes later)
Brief Answer:

Interaction between centramine and sertraline

Detailed Answer:

Hi,

Centramine can possibly interact with sertraline. They can both increase the toxicity or side effects of each other and can possibly lead to a condition called serotonin syndrome where there is an excess of the chemical serotonin in the body.

Both of these meds increase serotonin levels.

Excess serotonin, can cause symptoms such as agitation, confusion, increased heart rate, increased blood pressure, seizures, diarrhea along with a number of other symptoms.

You may want to consider speaking to the weight loss clinic about this possibility.

Hope I have answered your query.

Take care

Regards,
Dr Michelle Gibson James, General & Family Physician
Note: For further guidance on mental health, Click here.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Dr. Michelle Gibson

General & Family Physician

Practicing since :2001

Answered : 16845 Questions

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Are Centramine, Entresto And Carvedilol Safe To Take Together?

Brief Answer: Interaction between centramine and sertraline Detailed Answer: Hi, Centramine can possibly interact with sertraline. They can both increase the toxicity or side effects of each other and can possibly lead to a condition called serotonin syndrome where there is an excess of the chemical serotonin in the body. Both of these meds increase serotonin levels. Excess serotonin, can cause symptoms such as agitation, confusion, increased heart rate, increased blood pressure, seizures, diarrhea along with a number of other symptoms. You may want to consider speaking to the weight loss clinic about this possibility. Hope I have answered your query. Take care Regards, Dr Michelle Gibson James, General & Family Physician