Are There Interactions Between Valproate And Lamotrigine?

Posted on Wed, 16 May 2018

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Wed, 16 May 2018 Answered on

Fri, 1 Mar 2024 Last reviewed on

Question : Are there any side affects when patients have XXXXXXX prescribed Lamotrigine along with Vallproic Acid.
My son is on both and has been for many years. His epilepsy has never been well controlled.
Since we pu9t him onCBD oil have had remarkable success However are wondering about interactions with these drugs.
He has been losing mobility and we now have to have a wheelchair. WE are observing other symptoms as well

Answered by Dr. V. N. S. Parinam (30 minutes later)

Brief Answer:
Interactions between Valproate and Lamotrigine

Detailed Answer:
Hi,

Although there are no serious side effects or interactions between them, the treating doctor can monitor the levels of lamotrigine closely. It can be significant as Oral valproic acid increases levels of lamotrigine by slowing its metabolism by liver. So he has to titrate dose of lamotrigine.
What do you mean by CBD oil?
If your son is losing mobility, it could be some other reason. Would like to know what is the reason for epilepsy? There could be other co conditions with epilepsy leading to loss of mobility. In my opinion the above drugs may not be entirely responsible

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. V. N. S. Parinam (11 minutes later)

CBD oil is Cannabis oil made from Marijuana Plant without the THC hallucinate
Smnce he's been on the oil seizure epsiodes have decressed from 30 a month to 3-6a month

Answered by Dr. V. N. S. Parinam (1 hour later)

Brief Answer:
What is neurologist opinion about reducing mobility

Detailed Answer:
Ok I understand.
Was your Neurologist / Epilepsologist aware of this CBD oil use? Did he comment on the mobility issues?

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar