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Can Allopurinol Raise PSA Levels?

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Posted on Tue, 21 Feb 2017
Question: Can allopurinol raise PSA levels
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Answered by Dr. Bonnie Berger-Durnbaugh (1 hour later)
Brief Answer:
Information

Detailed Answer:
Hello,

I found this article that noted an increase of PSA released with allopurinol treatment, although the mechanism was not know.

Here is the article abstract: https://www.YYYYi.nlm.nih.YYY/YYYYYYY/0000

It says: "Hence, an increased release of PSA from the prostate gland was noted upon allopurinol treatment. The mechanism of the allopurinol-induced release is obscure."

Other than this one article, I could not find any other indication that allopurinol increases PSA.
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3133 Questions

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Can Allopurinol Raise PSA Levels?

Brief Answer: Information Detailed Answer: Hello, I found this article that noted an increase of PSA released with allopurinol treatment, although the mechanism was not know. Here is the article abstract: https://www.YYYYi.nlm.nih.YYY/YYYYYYY/0000 It says: "Hence, an increased release of PSA from the prostate gland was noted upon allopurinol treatment. The mechanism of the allopurinol-induced release is obscure." Other than this one article, I could not find any other indication that allopurinol increases PSA.