Can Bupropion Be Taken In Place Of Zoloft?

Posted on Sat, 7 Apr 2018

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Sat, 7 Apr 2018 Answered on

Fri, 11 Aug 2023 Last reviewed on

Question : My name is XXXXXXX XXXX, I am 53 and I have been taking Zoloft for well over 10 years now. While it does help, I want to change to something like Bupropian. What are your thoughts on the connection of how this will effect my moods.

Answered by Dr. Alexander H. Sheppe (-4 hours later)

Brief Answer:
Consultation

Detailed Answer:

Hello,

When a medicine has been working for so long, it is generally unwise to change it. If you are having any continued benefit at all, but are still having major symptoms of depression, using an augmenting medication might be helpful. Some examples of augmenting medications are bupropion (as you note), T3, mirtazapine, or lithium. I would get a referral to see a psychiatrist to talk about the pros and cons of adding a new medication.

Hope I have answered your query.

Regards,
Dr. Alexander H. Sheppe, Psychiatrist

Above answer was peer-reviewed by : Dr. Nagamani Ng