Can Doxepin Be Taken With Depakote, Lamictal, Zoloft And Rexulti?

Posted on Thu, 14 Dec 2017

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Thu, 14 Dec 2017 Answered on

Tue, 15 May 2018 Last reviewed on

Question : hello, can you take doxapin with depakote of Zoloft Lamictal and of rexulti? thank you

Answered by Dr. Dr. Michelle Gibson (34 minutes later)

Brief Answer:
some interactions can occur

Detailed Answer:
Hi, thanks for using healthcare magic

There are some interactions that would require monitoring but they can be used together.

The interactions are--(1) lamotrigine (lamictal) increases the toxicity of sertraline (zoloft)
(2)sertraline (zoloft) may increase the effect and level of brexiprazole (rexulti)
by affecting its break down
(3) Depakote increases lamotrigine (lamictal) by decreasing its breakdown

It is possible that you may not experience any side effects of these reactions but you should be monitored to see if any occurs

I hope this helps, feel free to ask any other questions

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar