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Can Etoricoxib Or Paracetamol Cause Elevated Liver Enzyme Levels?

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Posted on Tue, 17 Jan 2017
Question: Hi sir
Iam 24 year old and suffering from spondylo arthritis .ihave been taking etoricoxib (1 tablet on alternate day).my sgot is 86 and sgpt is 98. Last year also my sgpt and sgot are high and I gone through all the check up of liver including hepatitis c and hepatitis b which came out be negative .they also checked asma which is also negative. when I stopped taking the etoricoxib and indomethacin ,lft became normal.but when I again started to take this medicine ,my sgpt and sgot become high.i also noticed my liver is very much sensitive to paracetamol tablets.what should I do?
doctor
Answered by Dr. Dr. Praveen Tayal (30 minutes later)
Brief Answer:
Avoid pain killers for long duration.

Detailed Answer:
Hello,
Thanks for posting your query.
The pain killers like etoricoxib or paracetamol do affect the liver functions and cause a rise in liver enzymes. These enzymes return to normal baseline once the drug is stopped. This is a normal reaction. You can take some hepatoprotective medicines like ursodeoxycholic acid after consulting a gastroenterologist.
Do avoid taking pain killers on a regular basis. You can try hot compress and back strengthening exercises and do apply a local analgesic gel on the painful area.
I hope this answers your query.
In case you have additional questions or doubts, you can forward them to me, and I shall be glad to help you out.
Wishing you good health.
Regards.
Dr. Praveen Tayal.
For future query, you can directly approach me through my profile URL http://bit.ly/Dr-Praveen-Tayal

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Praveen Tayal (7 minutes later)
Sir whether this much rise in the level of sgpt and sgot is dangerous for liver?
My liver is also grade 1 fatty liver and I don't eat oily or junk food.what could be the reason of my fatty liver?my blood sugar always remain normal.
doctor
Answered by Dr. Dr. Praveen Tayal (27 minutes later)
Brief Answer:
This is a minor rise in liver enzymes.

Detailed Answer:
Hello.
Thanks for writing again.
This is just a very mild rise in liver enzymes. It is not dangerous. The fatty liver can be due to excessive body fat and degenerative change in liver tissue. Restricting the fat intake can reverse such a mild change. Please do not worry.
Hope my answer is helpful.
Do accept my answer in case there are no further queries.
Regards.
Note: For further queries, consult a joint and bone specialist, an Orthopaedic surgeon. Book a Call now.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Dr. Praveen Tayal

Orthopaedic Surgeon

Practicing since :1994

Answered : 12314 Questions

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Can Etoricoxib Or Paracetamol Cause Elevated Liver Enzyme Levels?

Brief Answer: Avoid pain killers for long duration. Detailed Answer: Hello, Thanks for posting your query. The pain killers like etoricoxib or paracetamol do affect the liver functions and cause a rise in liver enzymes. These enzymes return to normal baseline once the drug is stopped. This is a normal reaction. You can take some hepatoprotective medicines like ursodeoxycholic acid after consulting a gastroenterologist. Do avoid taking pain killers on a regular basis. You can try hot compress and back strengthening exercises and do apply a local analgesic gel on the painful area. I hope this answers your query. In case you have additional questions or doubts, you can forward them to me, and I shall be glad to help you out. Wishing you good health. Regards. Dr. Praveen Tayal. For future query, you can directly approach me through my profile URL http://bit.ly/Dr-Praveen-Tayal