Can Forteo Be Taken While Having Monoclonal Gammopathy Of Undetermined Significance?

Posted on Wed, 28 Mar 2018

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Thu, 29 Mar 2018 Answered on

Thu, 18 May 2023 Last reviewed on

Question : I have severe osteoporosis and 4 endocrinologists have wanted me to take Prolia. From what I've read, bone loss will recontinue if I do not take a medication like Forteo. However, I can't take Forteo because I have monoclonal gammopathy of undetermined significance. The doctors I've seen are not aware of the info. Hopefully, you can help. Of do you suggest I see a hematologist also? Thank you.

Answered by Dr. Mirjeta Guni (10 hours later)

Brief Answer:
About forteo and monoclonal gammopathy...

Detailed Answer:

Hello,

Recombinant human parathyroid hormone, teriparatide (Forteo), is a new compound that has been shown to be successful in the treatment of osteoporosis.

There are cases with monoclonal gammopathy of uncertain significance (MGUS) who developed malignant myeloma after teriparatide treatment and is suggested that in addition to malignant myeloma and smouldering myeloma, MGUS should also be considered contraindicated for teriparatide treatment.

I would suggest not to be treated with Forteo, probably the hematologist will convince your treating physician.

Hope I have answered your query.

Regards,
Dr. Mirjeta Guni, Endocrinologist

Above answer was peer-reviewed by : Dr. Yogesh D