Can Hydrocodone Be Taken After Aleve And Tylenol Intake?

Posted on Mon, 21 Apr 2014

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Mon, 21 Apr 2014 Answered on

Mon, 12 May 2014 Last reviewed on

Question : Can I take hydrocodone APAP 5/325 after taking 2 aleve and 2 extra strength tylenol (650mg) . I took the aleve and tylenol 8 hrs ago. I have a knee injury waiting for final diagnosis. I try to take OTC first but they just aren't working today.

Answered by Dr. Karl Logan (5 hours later)

Brief Answer: Yes you can take the hydrocodine now Detailed Answer: Hi, You can take the hydrocodine APAP safely now yes. you should not take this drug and Tylenol together but should substitute. You can take aleve with both. you should take no more that 4g of acetaminophen in one 24 hr period, that's up to 1g every 6 hours. Best wishes

Above answer was peer-reviewed by : Dr. Raju A.T

Follow up: Dr. Karl Logan (4 hours later)

I have been taking tylenol arthritis which is 650mg/tablet. The instructions say I can take 2 at a time but no more than 3 tablets in a 24hr. period. To clarify, are you saying its safer to take 1 tablet every 6 hours? When not using hydrocodone, my standby is the 2 aleve and 2 650 mg tylenol--this seems to be the level that abates the pain. I take this 4 to 5 days out of 7 . I have to take a break from the aleve due to reflux problems. Thx for your prompt response. Its a weekend and a week until my next MD appt. and it usually takes a couple of days to get an answer to a non urgent question from his office. Took the hydrocodone (just 1) and it did take the edge off the pain. Thx!

Answered by Dr. Karl Logan (6 hours later)

Brief Answer: Take 1 Tylenol arthritis and 1 hydrocodine APAP Detailed Answer: hi, why don't you take 1 Tylenol arthritis with a hydrocodine APAP every 6 hours. you will still be under 1g of acetaminophen and 4g in a 24 hour period. take 500mg of aleve twice a day. if Aleve bothers your stomach you should take ranitidine or omeprazole or an equivalent drug once a day. best wishes Karl

Above answer was peer-reviewed by : Dr. Vinay Bhardwaj