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Can I Take Benadryl While Taking Lisinopril, Flecainide And Xarelto?

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Posted on Mon, 3 Feb 2014
Question: I am having an mild allergic reaction. I am on lisinopril, flecainide, and xarelto. Can I take Benadryl?
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Answered by Dr. Vivek Chail (1 hour later)
Brief Answer: Significant drug interaction with Benadryl likely Detailed Answer: Hi XXXX, Thanks for writing in to us. Lisinopril is known to interact with diphenhydramine and cause further lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Flecainide oral will increase the level or effect of diphenhydramine-phenylephrine oral and vice versa by altering drug metabolism. Please have a discussion with your doctor before you take Benadryl. You may apply calamine lotion to the itching areas. Hope your query is answered. Do write back if you have any doubts. Regards, Dr.Vivek
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Vivek Chail

Radiologist

Practicing since :2002

Answered : 6874 Questions

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Can I Take Benadryl While Taking Lisinopril, Flecainide And Xarelto?

Brief Answer: Significant drug interaction with Benadryl likely Detailed Answer: Hi XXXX, Thanks for writing in to us. Lisinopril is known to interact with diphenhydramine and cause further lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Flecainide oral will increase the level or effect of diphenhydramine-phenylephrine oral and vice versa by altering drug metabolism. Please have a discussion with your doctor before you take Benadryl. You may apply calamine lotion to the itching areas. Hope your query is answered. Do write back if you have any doubts. Regards, Dr.Vivek