Brief Answer: Prolactin Detailed Answer: First, I would like to know your age, and if you are taking any medications. I have reviewed the attached lab result. The prolactin is just mildly elevated. Sometimes a stressful blood collection can lead to temporary rises in blood prolactin levels that quickly normalize. Such circumstances do not constitute any medical abnormality. I suggest you repeat the blood test for prolactin. Try avoiding a troublesome blood draw. Hopefully a good phlebotomist/technician can comfortably take your sample. There is no published literature to my knowledge that describes progesterone related problems in men. Your testosterone levels are fine, so even greater reason to not worry about the high progesterone. I suggest you also check your thyroid with the next set of labs along with a CBC and complete metabolic panel. Therefore the following tests are recommended 1 Prolactin 2 TSH 3 Free T4 4 CBC 5 Creatinine 6 Electrolytes 7 Liver function tests If you are truly elevated prolactin then further tests will be necessary to determine the cause and treatment will depend on the cause.

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Brief Answer: Follow up Detailed Answer: 1 Gilberts syndrome is not known to affect any hormones 2 Sertraline can cause low libido and impotence. It has also been associated with prolactin rise in less than 1% cases. If your repeat prolactin still comes back high, and your MRI of the pituitary is normal and your TSH and creatinine are normal, then discuss with your doctor who prescribes sertraline to see if this can be substituted for something else that would not cause libido and erection problems (and likely even reverse the prolactin elevation) 3 Sleep, sex and stress can also produce transient prolactin elevations to a very mild degree. This does not represent a problem 4 I did not say prolactin elevates progesterone. Further, it is estrogen that is more commonly associated with prolactin elevations. However, progesterone can cause galactorrhea (milky discharge form breasts in a non-pregnant adult).

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Brief Answer: Second follow up Detailed Answer: Treatment discussion is relevant only when a disorder is diagnosed. Pure progesterone excess is not described as a disease entity, to my knowledge. However, there are rare 'feminizing' tumors in males that produce excess female hormones but they are associated with an elevated estradiol as well as DHEAS, and low testosterone. Your estradiol and DHEAS are not high, and your testosterone is not low. So it does not fit the picture.

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