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Can Nexium Cause Alzheimer's Disease?
Posted on
Thu, 7 Apr 2016
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Thu, 7 Apr 2016
Answered on
Tue, 7 Jun 2016
Last reviewed on
Brief Answer:
there's no definite answer...
Detailed Answer:
Hello,
although there are studies linking nexium use (and other proton pump inhibitors, PPI) and Alzheimer's disease (AD) there's no proof that the drug is the cause. The studies focused on prescription data mostly and there is indeed a relation. One study showed that people who used PPI for a long time, had 44% more AD. Despite that, there is no certainty that the cause was the PPI.
Some potential mechanisms have been suggested, like reduced absorption of vitamin B12 or a direct effect of PPI on the brain, but no study has addressed this issue completely.
Alternatives include H2-receptor antagonists, prostaglandins, antacids.
I hope you find my comments helpful!
You can contact me again, if you'd like any clarification or further information.
Kind Regards!
there's no definite answer...
Detailed Answer:
Hello,
although there are studies linking nexium use (and other proton pump inhibitors, PPI) and Alzheimer's disease (AD) there's no proof that the drug is the cause. The studies focused on prescription data mostly and there is indeed a relation. One study showed that people who used PPI for a long time, had 44% more AD. Despite that, there is no certainty that the cause was the PPI.
Some potential mechanisms have been suggested, like reduced absorption of vitamin B12 or a direct effect of PPI on the brain, but no study has addressed this issue completely.
Alternatives include H2-receptor antagonists, prostaglandins, antacids.
I hope you find my comments helpful!
You can contact me again, if you'd like any clarification or further information.
Kind Regards!
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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