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Can Omeprazole Cause Kidney Disease?
Posted on
Fri, 20 Mar 2015
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Fri, 20 Mar 2015
Answered on
Mon, 6 Apr 2015
Last reviewed on
Question : I have ckd stage 3 and am taking omerprazole dr 20 mg a day for acid reflux or gerd. What is it doing to my kidneys and I have been taking it for 9 months now. My criatinine level has gone up in that time. What should I do. doctors here seem to be no help.
Michele
YYYY@YYYY
Michele
YYYY@YYYY
Brief Answer:
Did the CKD start before or after omeprazole
Detailed Answer:
Hello,
Welcome and thanks for your query.
I understand your concern.
Please let me know if the CKD was diagnosed before the start or after the start of Omeprazole for GERD. If it was before, omeprazole was not the cause. Was the cause of CKD determined? Most CKDs become worse with time and the elevation of blood creatinine value with time is the natural history of CKD.
Omeprazole rarely produces an interstitial nephritis which is a cause of CKD and progressive elevation of creatinine. So if the CKD started after you started omeprazole, it has to be considered in the causes irrespective of its rarity.
Did the CKD start before or after omeprazole
Detailed Answer:
Hello,
Welcome and thanks for your query.
I understand your concern.
Please let me know if the CKD was diagnosed before the start or after the start of Omeprazole for GERD. If it was before, omeprazole was not the cause. Was the cause of CKD determined? Most CKDs become worse with time and the elevation of blood creatinine value with time is the natural history of CKD.
Omeprazole rarely produces an interstitial nephritis which is a cause of CKD and progressive elevation of creatinine. So if the CKD started after you started omeprazole, it has to be considered in the causes irrespective of its rarity.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
ckd was diagnosed before the omeprazole for gerd. ckd was from unchecked high blood pressure so damaged my kidneys. am on low salt diet, atenolol 100mg, amlodipine besylate 10mg and lipitor 20mg. now have blood pressure under control and have been at ckd3 for 2 years now. have read should not be on omeprazole for more than 4 months and is not intended for long term use. am concrened about this.
Michele
Michele
Brief Answer:
Some conditions require long term acid suppression
Detailed Answer:
The duration of Omeprazole treatment is dependent on the condition for which it is taken.
For conditions like gastrinoma or ZE syndrome or Barett's esophagus are conditions that require long term acid suppression. Peptic ulcer and GERD would heal with a short duration of treatment like a couple of months. In such patients there may not be the need for long term strong acid suppression for symptomatic relief. This is a controversial area as some believe that long term acid suppression has untoward effects.
Some conditions require long term acid suppression
Detailed Answer:
The duration of Omeprazole treatment is dependent on the condition for which it is taken.
For conditions like gastrinoma or ZE syndrome or Barett's esophagus are conditions that require long term acid suppression. Peptic ulcer and GERD would heal with a short duration of treatment like a couple of months. In such patients there may not be the need for long term strong acid suppression for symptomatic relief. This is a controversial area as some believe that long term acid suppression has untoward effects.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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