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Can Oxycodone Be Taken Along With Lisinopril, Paxil And Clonazepam?

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Posted on Tue, 9 Sep 2014
Question: Started on lisinopril 10mg today because of high blood pressure (165/115) and headache for the last three weeks. I also take paxil 20 mg and clonazepam .5 mg. My headache is the worse that it's been in three weeks and I want to take oxycodone for the pain. Is this combination safe?
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Answered by Dr. Chakravarthy Mazumdar (2 hours later)
Brief Answer:
Combination is not safe

Detailed Answer:
Oxycodone does not go well with Paxil and Clonazepam. They have serious interactions. They cause intense sedation with clonazepam and sometimes respiratory depression.

You have to choose safer alternatives. I feel once the blood pressure comes down the headache should be tolerable.

Please take a local treating doctor opinion before using such combinations.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Aparna Kohli
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Answered by
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Dr. Chakravarthy Mazumdar

General & Family Physician

Practicing since :2004

Answered : 2242 Questions

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Can Oxycodone Be Taken Along With Lisinopril, Paxil And Clonazepam?

Brief Answer: Combination is not safe Detailed Answer: Oxycodone does not go well with Paxil and Clonazepam. They have serious interactions. They cause intense sedation with clonazepam and sometimes respiratory depression. You have to choose safer alternatives. I feel once the blood pressure comes down the headache should be tolerable. Please take a local treating doctor opinion before using such combinations.