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Can Praluent Be Taken When Allergic To Sulfa?
Question: Hello,
I have been prescribe Praluent and noticed in it's literature That it has a disulfide bond. I am very allergic to sulfa type drugs. Have you been aware of increases side affects from Praluent in people with my allergy problems?
Don't know that any reports of use except history of MI, three stents, and failure on Crestor due to fatigue and aching and moderately elevated LDL around 100, low normal HDL, Normal triglycerides.
I have been prescribe Praluent and noticed in it's literature That it has a disulfide bond. I am very allergic to sulfa type drugs. Have you been aware of increases side affects from Praluent in people with my allergy problems?
Don't know that any reports of use except history of MI, three stents, and failure on Crestor due to fatigue and aching and moderately elevated LDL around 100, low normal HDL, Normal triglycerides.
Brief Answer:
I would recommend as follows:
Detailed Answer:
Hello!
Welcome and thank you for asking on HCM!
Regarding your concern, I would explain that it is true that is composed by disulfide-linked heavy and light chains (which are made of aminoacids).
This means that it can cause a crossed allergic reaction, if you are so allergic to sulfa type drugs.
And in fact the most common adverse effect of this drug are allergic reactions, which have been encountered in up to 9.6% of the patients taking this drug.
Coming to this point, I would not recommend taking it.
As your LDL levels are just borderline, I would recommend starting another type of statin (atorvastatin) which is less potent than crestor. I would recommend starting in low doses (10mg per day) and increasing slowly up to 20mg.
If you experience adverse effects such as fatigue, muscular cramps even with this drug in these doses, I would recommend considering Zetia (ezetimibe).
You should discuss with your doctor on the above treatment options.
Another option (considering your borderline LDL levels) would be avoid medical therapy and use some natural ways to reduce LDL levels:
- diet modifications (avoid saturated fat and sugar, like sweats, butter, red meat, etc.) and increase food reach in fibers and in omega 3 fatty acids (olive oil, fish oil, fish, cashews, walnuts, etc.).
- try to lose some pounds especially if you are overweight
- perform a lot of physical activity (aerobics, walking, recreational sports, etc.).
Hope you will find this answer helpful!
Feel free to ask me again whenever you need!
Kind regards,
Dr. Iliri
I would recommend as follows:
Detailed Answer:
Hello!
Welcome and thank you for asking on HCM!
Regarding your concern, I would explain that it is true that is composed by disulfide-linked heavy and light chains (which are made of aminoacids).
This means that it can cause a crossed allergic reaction, if you are so allergic to sulfa type drugs.
And in fact the most common adverse effect of this drug are allergic reactions, which have been encountered in up to 9.6% of the patients taking this drug.
Coming to this point, I would not recommend taking it.
As your LDL levels are just borderline, I would recommend starting another type of statin (atorvastatin) which is less potent than crestor. I would recommend starting in low doses (10mg per day) and increasing slowly up to 20mg.
If you experience adverse effects such as fatigue, muscular cramps even with this drug in these doses, I would recommend considering Zetia (ezetimibe).
You should discuss with your doctor on the above treatment options.
Another option (considering your borderline LDL levels) would be avoid medical therapy and use some natural ways to reduce LDL levels:
- diet modifications (avoid saturated fat and sugar, like sweats, butter, red meat, etc.) and increase food reach in fibers and in omega 3 fatty acids (olive oil, fish oil, fish, cashews, walnuts, etc.).
- try to lose some pounds especially if you are overweight
- perform a lot of physical activity (aerobics, walking, recreational sports, etc.).
Hope you will find this answer helpful!
Feel free to ask me again whenever you need!
Kind regards,
Dr. Iliri
Note: For further queries related to coronary artery disease and prevention, click here.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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