Can Trazodone, Lamictal, Alprazolam And Brintellix Be Taken Together?

Posted on Fri, 23 Oct 2015

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Fri, 23 Oct 2015 Answered on

Tue, 10 Nov 2015 Last reviewed on

Question : I am taking 350 mg trazodone, 400 mg lamictal, 7 mg alprozalom (throughout the day, and have been prescribed 5 mg brintellix. Will the trazodone and brintellix be a major problem? Thank you.

Answered by Dr. Swarnava Dattagupta (1 hour later)

Brief Answer:
It can cause a rare phenomenon called serotonin syndrome

Detailed Answer:
Hi,
Thank you for posting your query in healthcaremagic.com
This is Dr. Swarnava dattagupta answering your query.

I understand your concern.
You are somewhat right in your query and there exists chances of a rare yet potentially dangerous condition called serotonin syndrome. When antidepressants are used in larger doses or used in combinations, this can precipitate. It precipitates mostly during the initial use of the combination therapy. It is because of the drug interaction that occurs between these two medicine and may lead to symptoms like increased heart rate, sweating, shivering, confusion, seizures, nausea, vomiting, blurred vision, muscle spasm etc.
Hence my suggestion would be to talk to your treating doctor about this and if he/she approves, then only continue with the medications.

Hope i have answered your question.
If you have any further questions i will be happy to help.
Regards

Above answer was peer-reviewed by : Dr. Vinay Bhardwaj

Follow up: Dr. Swarnava Dattagupta (19 minutes later)

Thank you.

Answered by Dr. Swarnava Dattagupta (18 minutes later)

Brief Answer:
You are welcome

Detailed Answer:
Hello.
You are most welcome.
You can ask me any further queries and I would be happy to help.
Otherwise you can close the discussion.

Wish you good health.
Regards.

Above answer was peer-reviewed by : Dr. Vinay Bhardwaj