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Can Wysolone Cause Weight Gain And Mood Swings In Children?

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Posted on Mon, 6 Jul 2015
Question: My kid has LKS - Landaul Kleffner Syndrome .He is 4 yrs and 3 months and has been advised it alongwith other medicines by paediatric neurologist.Hpowever after 1 month of its intake his weight has grown by 9 kgs and his hyperacitivity has increased tremendously and his vocabulary has reduced sharply of late alongwith swelling type features on his face and much of the body.he passes urine & potty too with out telling / hinting.Are these the side effects of Wysolone and will they pass off and child will normalise once the medication is stopped altogether ? Plz respond urgently .Thx !
The medicine is WYSOLONE - having main compound as PREDNISONE.Currently for the past 16 days he is taking 20mg of it daily.Prior to it for a fortnight he took 30mg of WYSOLONE.and prior to it for 7 days he took 40 mg per day of WYSOLONE.
doctor
Answered by Dr. Archana Verma (1 hour later)
Brief Answer:
Hi

Detailed Answer:
Hi
Welcome to the HCM
I understand your concerns.

-The weight gain and mood changes seen in your child can be due to the current medical treatment of steroids he is receiving. They usually improve once the dose of steroids is reduced and gradually stopped.

-The speech deterioration seen in your child is due to the course of landau kleffner syndrome. In the typical case, a child between 3 and 7 years of age experiences language problems, with or without seizures.

-Seizures are usually few and often occur during sleep. Poor control can lead to further deterioration of speech. Clobazam and levetiracetam are good alternative drugs to epilex for controlling seizures which you can discuss with your doctor.

Multiple subpial transections (MSTs) have been used with variable success in patients with landau kleffner syndrome.

Hopefully this will help you. In case of any further questions, you may contact me.
Take care.

Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
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Follow up: Dr. Archana Verma (7 hours later)
Thank you Doctor for your response !

Plz help me explain this line further : "Multiple subpial transections (MSTs) have been used with variable success in patients with landau kleffner syndrome".

Thx !
Dear Doctor please address this line : " he passes urine & potty too with out telling / hinting.Are these the side effects of Wysolone and will they pass off and child will normalise once the medication is stopped altogether ? " Thx !


doctor
Answered by Dr. Archana Verma (42 minutes later)
Brief Answer:
wait before opting for mutiple subpial transection

Detailed Answer:
Multiple subpial transections is a new modality of treatment for Landau Kleffner Syndrome, in which multiple small slices are made in brain cortex. This helps to halt the seizure discharge spreading in the cortex which may improve both the EEG abnormalities and the language disorder in a small number of children. This procedure is still being studied in various epilepsy centers.
I would recommend you to wait for the response of medications first and in case the favourable response doesn't come, you may opt for this.

The problem with poops and pee is not a known side effect of wysolone. It seems to be due to the communication skill deterioration from the disease per se. Hopefully this will improve with further toilet training and proper control of seizures.

Hope I have answered your question. If you have any further questions I will be happy to help. If you do not have any clarifications, you can close the discussion and rate the answer.
Wish you good health for your child.
Take care
Note: For further queries related to your child health, Talk to a Pediatrician. Click here to Book a Consultation.

Above answer was peer-reviewed by : Dr. Prasad
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Answered by
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Dr. Archana Verma

Pediatrician

Practicing since :2006

Answered : 1129 Questions

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Can Wysolone Cause Weight Gain And Mood Swings In Children?

Brief Answer: Hi Detailed Answer: Hi Welcome to the HCM I understand your concerns. -The weight gain and mood changes seen in your child can be due to the current medical treatment of steroids he is receiving. They usually improve once the dose of steroids is reduced and gradually stopped. -The speech deterioration seen in your child is due to the course of landau kleffner syndrome. In the typical case, a child between 3 and 7 years of age experiences language problems, with or without seizures. -Seizures are usually few and often occur during sleep. Poor control can lead to further deterioration of speech. Clobazam and levetiracetam are good alternative drugs to epilex for controlling seizures which you can discuss with your doctor. Multiple subpial transections (MSTs) have been used with variable success in patients with landau kleffner syndrome. Hopefully this will help you. In case of any further questions, you may contact me. Take care.