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Can You Take Duromine 30 Mg Daily With Sertraline 25 Mg Daily?

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Posted on Thu, 27 Aug 2020
Twitter Thu, 27 Aug 2020 Answered on
Twitter Mon, 14 Jul 2025 Last reviewed on
Question : Hi. Can you take duromine (30 mg daily) with Sertraline (25 mg daily)?
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Answered by Dr. Aaron Branch (20 minutes later)
Brief Answer:
Serious interaction

Detailed Answer:
Hello, I'm Dr. Branch, thanks for using 'Ask a Doctor'. Duromine (phentermine) and sertraline do have a serious interaction, in which both increase the toxicity of the other, which could lead to serious reactions, such as serotonin syndrome. While the sertraline dose is not a large dose, and so it may not be a problem using both, I would certainly only take these medications together under the advise of a doctor who can follow you and monitor you for any side effects. Also, it may be possible to use a different medication that doesn't have this serious interaction, depending on the reasons you are taking both of these medications and your other history.

I hope that helps, please let me know if you have any other questions about that, and I would be glad to discuss it with you further.
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Above answer was peer-reviewed by : Dr. Kampana
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Dr. Aaron Branch

General & Family Physician

Practicing since :2011

Answered : 1200 Questions

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Can You Take Duromine 30 Mg Daily With Sertraline 25 Mg Daily?

Brief Answer: Serious interaction Detailed Answer: Hello, I'm Dr. Branch, thanks for using 'Ask a Doctor'. Duromine (phentermine) and sertraline do have a serious interaction, in which both increase the toxicity of the other, which could lead to serious reactions, such as serotonin syndrome. While the sertraline dose is not a large dose, and so it may not be a problem using both, I would certainly only take these medications together under the advise of a doctor who can follow you and monitor you for any side effects. Also, it may be possible to use a different medication that doesn't have this serious interaction, depending on the reasons you are taking both of these medications and your other history. I hope that helps, please let me know if you have any other questions about that, and I would be glad to discuss it with you further.