Does Methylphenidate Interact With Glipizide, Lantus, Buspirone, Trazodone, Lorazepam And Remeron?

Posted on Mon, 5 Dec 2016

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Mon, 5 Dec 2016 Answered on

Tue, 27 Dec 2016 Last reviewed on

Question : I am a diabetic taking glypizide 5mg twice daily Lantus Insulin12 units bed time, Buspironne HCl 10mg 1 tab 3 times daily Trazodone 300mg bedtime and lorezepam prn , Remron 15mg 1 tab Bed time . As you can see I am suffering from Deep depression and Insomnia also . My Doctor has prescribed Methylphenidate 10mg twice daily recently to be a stimulant and help me to focus . Having added this Methylpenidate After one application I feel already feel over stimulated . Please advise as what to do because I am not sure if all these medications are working together . I already feel as if falling asleep is getting worse .
Thank you .

Answered by Dr. Rahul Tawde (1 hour later)

Brief Answer:
You are using a CNS stimulant that is depriving your sleep.

Detailed Answer:
Hello, Thank you for posting your question on Health Care Magic.
I very well understand the predicament you are going through.
From the diabetes point of view everything looks well managed with insulin.
But you are using lorazepam which is a central nervous system suppressant, and a good sedative and anxiolytic.
At the same time you are using methylphenidate which is a stimulant used for keeping awake.
If sleep is a problem I would suggest you to wean out methylphenidate.
Hope this helps
Best wishes

Note: For further follow-up, discuss your blood glucose reports with our diabetologist. Click here.

Above answer was peer-reviewed by : Dr. Raju A.T