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Does Mifepristone Have Any Adverse Effects Of Follicular Growth?

Posted on Tue, 16 Dec 2014

Question: I am XXXXXXX 27 F married 2 years ago.I have small multiple intramural fibroids.before last may 2014 my periods wer regular.i have taken small dosage mifepristone tablet for one month to reduce fibroids.From that onwards my periods were irregular.i have done my follicular study RECENTLY from 10th day to 25th day but they were small follicles+ on both ovaries.so my doctor gave fsh injections on 2nd ,4th,6th and 8th day f my menstrual cycle.BUT ON 10TH DAY MY FS DONE STILL THEY WERE SMALL FOLLICLES+ ON BOTH OVARIES.what i have to do to increase my follicles? is mifepristone be the cause of no follicular growth.is there any chance of increaing my follicle size or else i have to go for a donor egg?Pl suggest me ?

Answered by Dr. Dalia Muraleedharan (41 minutes later)

Brief Answer:
Dont worry

Detailed Answer:
Hi,
Thanks for writing..
I understand your concern..

Mifepristone could have affected the ovary .. But there is no proven data to say that it causes anovulation.. There are many people who ovulate normaliy in 2-3 months after mifepristone.. So dont worry..

I would suggest a combination of clomiphene for 5 days and Recombinent FSH for next 3 days to stimulate your ovaries.. Follow up follicular scan on day 11. Continue follicular study on alternate day to see the developing follicle till follicle size reaches 20x20mm which is the time ovulation occurs.. You should have intercourse around this time.. Increase the dose of clomiphene and rFSH till ovulation occurs.. This can be tried for a period of 6 months before taking a decision of donor egg..

Get an AMH to know the ovarian reserve and husband's semen analysis prior to starting the treatment..

If you are have gained a lot of weight, reduce the weight and strict diet control should be followed.. This helps to regularise periods..

Hope I have answered your query..Feel free to ask any doubts.. good day

Above answer was peer-reviewed by : Dr. Bhagyalaxmi Nalaparaju

Follow up: Dr. Dalia Muraleedharan (13 minutes later)

my husbands sperm count 170 million out of this active 55 percent.i have tried fsh injections from 2nd day to 8th day.on 10th day no growth of follicle.still i have to wait for some days to increase follicle size or else i have to continue taking fsh injections more.

Answered by Dr. Dalia Muraleedharan (1 hour later)

Brief Answer:
Continue with follicular study

Detailed Answer:
Hi,
Thanks for writing..

Continue with follicular study in this cycle for 2 more alternate days.. If there is no follicle developing, This cycle nothing can be done.. Clomiphene from day 2 to day 6 and rFSH from day 7 to 9 has to be taken in the next cycle and follow up with follicular study to see the developing follicle..

Hope i have answered your query..Feel free to ask any doubts.. good day

Note: Revert back with your gynae reports to get a clear medical analysis by our expert Gynecologic Oncologist. Click here.

Above answer was peer-reviewed by : Dr. Bhagyalaxmi Nalaparaju