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Does Oxycodone Interact With Antidepressants?

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Posted on Sun, 26 Feb 2017
Twitter Sun, 26 Feb 2017 Answered on
Twitter Tue, 21 Mar 2017 Last reviewed on
Question : I see my familey doctor regaulrey. I get pain medicine for a back injury. Oxycodone 15 mg.I have been diagnosed and treated for depression. I think I need a anti deppresent. Will my doctor stop giveing me my pain medicine If I ask for prozac
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Answered by Dr. Bonnie Berger-Durnbaugh (41 minutes later)
Brief Answer:
Information

Detailed Answer:
Hello XXXXXXX

I can understand your concern. It is ok to take an antidepressant and opiate. There is some association in the pharmacological literature that SSRI antidepressants and opiates together can excessively increase serotonin levels (serotonin syndrome), which occurs rarely - but we often give this combination. There are other classes of antidepressants as well.

You may find, after taking an antidepressant for several months, that you need less of the oxycodone.

However, I don't think your doctor will automatically want to discontinue the oxycodone because you also need an antidepressant.

I hope this information helps. Please let me know if I can provide further information.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3133 Questions

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Does Oxycodone Interact With Antidepressants?

Brief Answer: Information Detailed Answer: Hello XXXXXXX I can understand your concern. It is ok to take an antidepressant and opiate. There is some association in the pharmacological literature that SSRI antidepressants and opiates together can excessively increase serotonin levels (serotonin syndrome), which occurs rarely - but we often give this combination. There are other classes of antidepressants as well. You may find, after taking an antidepressant for several months, that you need less of the oxycodone. However, I don't think your doctor will automatically want to discontinue the oxycodone because you also need an antidepressant. I hope this information helps. Please let me know if I can provide further information.