Does Pentoxifylline 400MG Together With Vitamin E Tab Will Interact With Apixaban?

Posted on Fri, 17 Nov 2023

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Fri, 17 Nov 2023 Answered on

Wed, 7 Feb 2024 Last reviewed on

Question : Good day. My mother-in-law is 83 years old with history of stroke, high blood pressure and high cholestrol. She is on medications including Apixaban, Metoprolol, and Atorvastain on regular basis. She is about to start a dental surgery procedure in a week. To help with healing, the dental surgeon suggested her to take Pentoxifylline 400MG together with Vitamin E. However, as Pentoxifylline is to enhance blood flow and Vitamin E has some blood thinner property, I wonder how these 2 medication will interact with Apixaban, the blood thinner she is taking. She currently takes Apixaban 2.5mgx2 daily. We will consult her pharmacist as well but hope to seek you opinion as well. Thank you!

Answered by Dr. Ilir Sharka (4 hours later)

Brief Answer:
I would explain as follows:

Detailed Answer:
Hello,

I understand your concern and would explain that it is ok to take vitamin E and pentoxyphylin concomitantly with apixaban as there are no interactions between these drugs.

Anyway it is important to stop apixaban 12 hours before the procedure in order to avoid possible bleeding.
Hope you will find this information helpful!

I would be glad to assist you again in case of further questions whenever you need!

Kind regards,

Dr. Iliri

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar