Does Alcohol Interact With Diphenhydramine In An Obese Person?

Posted on Wed, 31 May 2017

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Wed, 31 May 2017 Answered on

Sat, 17 Jun 2017 Last reviewed on

Question : My ast and alt enzymes are high. I take ambien each night. Sometimes, if sleep doesn't come easily I'll also take a diphenhydramine. I will also drink 3 or 4 glasses of wine or beer a week. I'm about 20 lbs overweight. Little actvity. Could eat better and am a 58 year old, female. I have also probably misused OTC meds like ibuprofen and Tylenol. Any idea which of these would be doing the most harm?

Answered by Dr. Sunil (42 minutes later)

Brief Answer:
Stop all hepatotoxic drugs.

Detailed Answer:
Hi,
Thanks for choosing HealthcareMagic for your query.
I am a Gastroenterologist and would answering your query.

Have seenyour details.
As per your query most likely cause of damage to liver is by use of anti inflammatory pills.
They are all metabolised by liver and are hepatotoxic in nature.
Even hypnotic like zolpidem you are on.
Alcohol also in high quantity is hepatotoxic.So the most likely cause of problem in your case is hepatoxicity due to overuse of medicine.

As per your question-
Ibuprofen and Zolpidem(As direclty metabolised by liver) should not be used.

Take liver rejenuvators like Sylimarin once daily along with anti oxidants to help liver to counter the toxicity.

In case you have any other query feel free to ask.
Thanks.

Above answer was peer-reviewed by : Dr. Nagamani Ng