Does Crushing A Pill And Using It, Cause Reduced Medicinal Effects On Consumption?

Posted on Mon, 5 Feb 2018

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Mon, 5 Feb 2018 Answered on

Mon, 24 Sep 2018 Last reviewed on

Question : my husband is 89 and the skin on his front part pf his leg sluffing off and leaving a large rectangular area (3x6 inches) THAT IS constantly oozing fluid his trouser legs are always wet. Doc proscribed furosemide. hr wont takr it what if I mash it up and put in his foo? Thanks, worried wife.

Answered by Dr. Suresh Heijebu (2 hours later)

Brief Answer:
Bioavailability of the drug reduces.

Detailed Answer:
Hello Ma'am,

I can certainly understand your concern.I have worked through your attached query in detail.

Bioavailability,(fraction of drug available for systemic absorption)often decreases when a pill is crushed and mixed with food .

But if he is really adamant in taking the pill, you have no option Left.

Hope I have answered your query.
Let me know if I can assist you further.

Regards,
Dr. Suresh Heijebu,
General & Family Physician.

Above answer was peer-reviewed by : Dr. Yogesh D