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Does Decreased Growth Hormone Level Have Capacity To Cause Some Growth?

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Posted on Sat, 14 Jun 2014
Question: Hi there,

Normally at end of puberty , growth hormones decline. lets suppose certain internal organs havnt finished growing yet...does a decreased growth hormone level still have capacity to cause some growth ??
doctor
Answered by Dr. Binu Parameswaran Pillai (2 hours later)
Brief Answer:
Hello

Detailed Answer:
Hello XXXXXXX

Good day.
Growth of organs are not determined by growth hormone alone. Growth need combined actions of several factors and hormones. For example, Growth hormone.Thyroid hormone, parathyroid hormone related peptide ( PTHrP), good nutrition, genetic factors etc.

As you rightly pointed out, growth hormone secretion is at its maximum at puberty. During that time, mainly skeletal growth and final development of sex organs occurs.
However, skeletal and sex organ development need contribution from sex hormones ( testosterone, estrogen etc) and thyroid hormones as well .

Now coming to your question, if any organ hasnt developed fully during puberty, there still can be some growth of the organs due to the action of other hormones ( which i mentioned earlier) . Factors like IGF-1 ( insulin like growth factor), Insulin etc also has growth promoting actions.

This is a tough question and i have tried to explain it at my level best. Please feel to ask further if you need clarifications.

Regards
Binu


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Binu Parameswaran Pillai (2 hours later)
Thank you Dr XXXXXXX for the beneficial answer.

Regarding if organ hasnt fully developed during puberty, you mention action from other hormones can help with growth...but what about the 'low' growth hormone itself, even if low can it still contribute to some growth?

It sounds as though there needs to be certain 'target level' for growth hormone to be present before growth can occur?

Best Regards XXXXXXX
doctor
Answered by Dr. Binu Parameswaran Pillai (1 hour later)
Brief Answer:
Hello

Detailed Answer:
Hello,

Yes, the low levels of GH can still promote some growth beyond puberty, ( but not beyond the maximum growth potential of organ). There should be a target level of GH for the actions to occur. Besides, the target organ should have enough receptors for GH and IGF-1 for growth to occur.

If GH is in excess ( as in conditions like Acromegaly, it can promote excessive organ growth in adult life too)
Regards
Binu


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Binu Parameswaran Pillai (4 days later)
Thank you Dr XXXXXXX for your valued answer.

I have a question regarding steroids i took age 14, and its effects on my behaviour. Its possible this drug caused me to be aggresive...but would this have been my first experience of 'androgen influenced aggresive behavior' ??

I know we have high androgens as babies but not sure if it led to aggression back then?

Thanks and Best Regards

doctor
Answered by Dr. Binu Parameswaran Pillai (9 minutes later)
Brief Answer:
Hello

Detailed Answer:
Hello,
Good day.
Yes, i remember you. I had answered your puberty initiation relted questions last month. Hope you are doing well.
Yes, puberty initiation with steroid hormones ( androgens) can cause some aggressive behaviour. But as i mentioned earlier, this is not the only responsible factor for aggression. In that case all males will be aggressive at puberty. Aggression is enhanced by androgens, but a component of family/society etc influence this.

Adult range of androgens are produced in male babies starting one month after birth until around 6 months after birth. This is important for sexual organ development and is called as XXXXXXX puberty. This will bring in some aggression, but new born brains are too immature to express this aggression. Often male babies are difficult to control aompared to female babies.

Kind Regards
Binu
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Binu Parameswaran Pillai

Endocrinologist

Practicing since :2003

Answered : 1439 Questions

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Does Decreased Growth Hormone Level Have Capacity To Cause Some Growth?

Brief Answer: Hello Detailed Answer: Hello XXXXXXX Good day. Growth of organs are not determined by growth hormone alone. Growth need combined actions of several factors and hormones. For example, Growth hormone.Thyroid hormone, parathyroid hormone related peptide ( PTHrP), good nutrition, genetic factors etc. As you rightly pointed out, growth hormone secretion is at its maximum at puberty. During that time, mainly skeletal growth and final development of sex organs occurs. However, skeletal and sex organ development need contribution from sex hormones ( testosterone, estrogen etc) and thyroid hormones as well . Now coming to your question, if any organ hasnt developed fully during puberty, there still can be some growth of the organs due to the action of other hormones ( which i mentioned earlier) . Factors like IGF-1 ( insulin like growth factor), Insulin etc also has growth promoting actions. This is a tough question and i have tried to explain it at my level best. Please feel to ask further if you need clarifications. Regards Binu