Thank you for your suggestions. I want to be clear, the
weight loss is not really unexplained. The
nausea and early satiety prevent adequate intake, which has led to the weight loss.
I neglected to mention that a recent PET scan, looking for metastatic cancer, was normal.
The suggestion of a non-GI source of the problem is interesting. We will consider a brain MRI, although I don't think metastatic breast Ca is much of a worry. Worth checking, though.
Nausea has been a problem even when
Crestor was stopped, so it was restarted. She has been on Zyrtec for over 10 years.
The GIST is very small, 1.5cm, and
biopsy with
endoscopic ultrasound was not successful. At some point she may have this tumor removed, anyway, although no one seems to believe it can cause her nausea.
Although the indications are quite weak (nausea but little pain and normal LFTs), we are considering ERCP with stent for possible Sphincter of Oddi dysfunction.