Hello Dr. I Am Wondering If There Is A Substance

Posted on Thu, 16 May 2019

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Thu, 16 May 2019 Answered on

Last reviewed on

Question : Hello Dr.

I am wondering if there is a substance that will slow the metabolism of trazodone or nefazodone. I am very sensitive to the effects of the mCPP metabolite And I have a mutated gene for 2d6 (I metabolized mCPP very slowly).

I am looking to maximize the affect of the parent drug in either case (5ht2 antagonism) whereas mCPP causes agitation in me. I also take modafinil, which speeds the metabolism of trazodone/nefazodone.

Thank you

Answered by Dr. Seikhoo Bishnoi (14 hours later)

Brief Answer:
The effect will not have clinical benefits.

Detailed Answer:
Hello thanks for using ask a doctor service

Trazodone is metabolised by multiple ways and one of this is by CYP3A4. Inhibitors of CYP3A4 can theoretically increase levels of Trazodone but I am afraid this would not be very useful clinically.

Antibiotics like erythromycin, clarithromycin etc, ketoconazole, grapefruit etc are inhibitors. But should not be used clinically to increase the effects.

Thanks.

Above answer was peer-reviewed by : Dr. Vaishalee Punj