question-icon

Hi I Am Currently Switching Medications From Viibryd 15 Mg

default
Posted on Tue, 16 Oct 2018
Question: Hi i am currently switching medications from Viibryd 15 mg to Zoloft. My doctor gave me a script for 50 mg but did not tell me about how to transition. Please let me know. Should I start with the 50? Or 25 and if 25 for how long until I go to 50? Viibryd worked very well for me but unfortunately too many GI problems and also we want to get pregnant and I hear its less studied for that. Please let me know plan for least side effects. Thanks!
doctor
Answered by Dr. Seikhoo Bishnoi (25 minutes later)
Brief Answer:
Zoloft 25 mg should be starting dose.

Detailed Answer:
Hello thanks for using ask a doctor service

Viibryd helps to improve serotonergic neurotransmission. Zoloft works in similar manner but the mechanism of action is different. The dose of 15 mg is not a high dose and you can stop the drug from first day only.

Instead of Viibryd dose you can take 25 mg Zoloft. Starting with low dose will minimise the first dose side effects. In around 7-10 days you can increase the dose of Zoloft to 50 mg and this should work for you. If needed the dose can be increased further to 75 or 100 mg.

Zoloft has been studied in pregnant ladies too and the drug is considered as safest antidepressant in pregnancy. Though the drug falls in category C.

Thanks

I hope this helps, please let me know if you need further assistance.
Above answer was peer-reviewed by : Dr. Yogesh D
doctor
doctor
Answered by Dr. Seikhoo Bishnoi (13 minutes later)
Brief Answer:
Viibryd blocks serotonergic receptors.

Detailed Answer:
Hello again

Viibryd has different mechanism of action than Zoloft. This means the pharmacological mechanisms, this doesn't mean that there are huge differences in efficacy or actions.

Viibryd acts as serotonergic receptor inhibitor similar to Zoloft which is SSRI, but at molecular levels the drug acts on difference receptors.

In short both drugs increase serotonergic neurotransmission but the mechanism is different. You can stop Viibryd completely and start with Zoloft. Zoloft will check any withdrawal symptoms.

Thanks.
Above answer was peer-reviewed by : Dr. Yogesh D
doctor
default
Follow up: Dr. Seikhoo Bishnoi (6 minutes later)
What do you mean by the fact that viibryd and zoloft have different mechanisms?

Viibryd worked well for me so I am slightly nervous to try something else. Please explain.
Answered by
Dr.
Dr. Seikhoo Bishnoi

Psychiatrist

Practicing since :2007

Answered : 5192 Questions

premium_optimized

The User accepted the expert's answer

Share on

Get personalised answers from verified doctor in minutes across 80+ specialties

159 Doctors Online

By proceeding, I accept the Terms and Conditions

HCM Blog Instant Access to Doctors
HCM Blog Questions Answered
HCM Blog Satisfaction
Hi I Am Currently Switching Medications From Viibryd 15 Mg

Brief Answer: Zoloft 25 mg should be starting dose. Detailed Answer: Hello thanks for using ask a doctor service Viibryd helps to improve serotonergic neurotransmission. Zoloft works in similar manner but the mechanism of action is different. The dose of 15 mg is not a high dose and you can stop the drug from first day only. Instead of Viibryd dose you can take 25 mg Zoloft. Starting with low dose will minimise the first dose side effects. In around 7-10 days you can increase the dose of Zoloft to 50 mg and this should work for you. If needed the dose can be increased further to 75 or 100 mg. Zoloft has been studied in pregnant ladies too and the drug is considered as safest antidepressant in pregnancy. Though the drug falls in category C. Thanks I hope this helps, please let me know if you need further assistance.