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History Of Anxiety. I Have Been Under A Psychiatrist's Care
Posted on
Fri, 27 Dec 2019
Medically reviewed by
Ask A Doctor - 24x7 Medical Review Team
Fri, 27 Dec 2019
Answered on
Last reviewed on
Question : History of anxiety. I have been under a psychiatrist's care but have realized a lot of my problems have been due to excess acetylcholine. SSRI'S are anticholinergic so they helped me to great extent but not completely. However SSRI'S only target the muscarnic receptors and not the nicotine receptors. I realized that nicotine, acetylcholine and ethanol can all activate the nicotinic receptors in the adrenal medulla and the potential action is secretion of adrenaline. So I do have high adrenaline as well in urine test
In fact a drug that was used for hypertension was actually a nicotine antagonist. So there is a connection between acetylcholine (nicotinic receptors) and adrenaline.
Anytime I eat foods high in choline like egg, meat etc.. I feel overstimulated and terrible.
I tested my pseudo cholinesterase enzyme and it shows the enzyme being overloaded. I test it again after eating foods high in choline and the cholinesterase enzyme value shoots up..
I have PON1 (Paroxanase) Mutations and eating nightshades makes me feel horrible. I am now certain that excess acetylcholine is the root cause of a my problems.
How do we solve this? Any ideas
In fact a drug that was used for hypertension was actually a nicotine antagonist. So there is a connection between acetylcholine (nicotinic receptors) and adrenaline.
Anytime I eat foods high in choline like egg, meat etc.. I feel overstimulated and terrible.
I tested my pseudo cholinesterase enzyme and it shows the enzyme being overloaded. I test it again after eating foods high in choline and the cholinesterase enzyme value shoots up..
I have PON1 (Paroxanase) Mutations and eating nightshades makes me feel horrible. I am now certain that excess acetylcholine is the root cause of a my problems.
How do we solve this? Any ideas
Brief Answer:
Newer antidepressants may be useful.
Detailed Answer:
Hello and welcome to "Ask a Doctor" service.
I have read your query and here is my advice.
Acetylcholine and adrenaline are antagonists, in other words, they result in contrary mechanisms in the body.
It is true that the stimulation of certain nicotinic receptors in the adrenal medulla may release adrenaline.
In your case, you should avoid substances or foods that give you this effect.
I think that in your case newer antidepressants such as SNRI (duloxetine for example) may help with the depression.
Discuss with your Doctor for these issues.
Hope you found the answer helpful.
Let me know if I can assist you further.
Newer antidepressants may be useful.
Detailed Answer:
Hello and welcome to "Ask a Doctor" service.
I have read your query and here is my advice.
Acetylcholine and adrenaline are antagonists, in other words, they result in contrary mechanisms in the body.
It is true that the stimulation of certain nicotinic receptors in the adrenal medulla may release adrenaline.
In your case, you should avoid substances or foods that give you this effect.
I think that in your case newer antidepressants such as SNRI (duloxetine for example) may help with the depression.
Discuss with your Doctor for these issues.
Hope you found the answer helpful.
Let me know if I can assist you further.
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Answered by
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