How Long After Sulpiride Dosage Does It Take Effect?

Posted on Mon, 21 Dec 2015

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Mon, 21 Dec 2015 Answered on

Thu, 7 Jan 2016 Last reviewed on

Question : Hi,
I am taking Lexapro 15 mg, Solian 100 mg (amisulpride), Klonopin 3 mg and Keppra 1000mg. My psychiatrist just decided four days ago to give me 25 mg of Sulpiride to help to stop dopaminergic activiity of Solian at low dose. I just would like to know how long does it take to Sulpiride to work.
Thanks, XXXXXXX

Answered by Dr. Dr. Ashok Kumar Choudhary (1 hour later)

Brief Answer:
It takes two to four weeks

Detailed Answer:
Dear XXXXXXX
Thanks for posting to Healthcaremagic.

I read your query and understand your concerns.

Sulpiride a typical antipsychotic, structurally similar to solian takes about at least two weeks to show clinically significant effects. In majority of cases the effect is complete by four weeks.

So it can be said that you will feel difference in desired outcome over a period of two to four weeks.

I hope this answers your question.
If you have more questions feel free to write back to me.
Thanks and regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Ashok Kumar Choudhary (1 hour later)

Dear Dr. XXXXXXX
Thank you for your answer, i just don't understand when you say that Sulpiride is structurally similar to Solian. As far as i know, there is no dopaminergic activity in Sulpiride, but there is in Solian at low dose. Am I right? In this case Sulpiride can stop the dopaminegic activity fo Solian?
Thanks a lot, XXXXXXX

Answered by Dr. Dr. Ashok Kumar Choudhary (7 hours later)

Brief Answer:
yes you are right

Detailed Answer:
Dear XXXXXXX
Thanks for reverting back to me.

You are right in saying that sulpiride do not have dopaminrgic effect at low dosages. In addition it does not have serotonergic effects alike amisulpiride which helps in obsessive compulsive disorder.

So you are right in saying that sulpiride do not have dopaminrgic effects at low dodage and rational treatment optionin Ocd.

I hope this helps you.
Thanks and regards.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Ashok Kumar Choudhary (9 hours later)

Dear Dr. XXXXXXX
Thanks a lot, it's clear. I have a last question: how long it takes to Solian to work? I was on Solian 50 mg during a month and i i am back on Solian 100 mg since 2 weeks.
Thanks beforehand, XXXXXXX

Answered by Dr. Dr. Ashok Kumar Choudhary (2 hours later)

Brief Answer:
maximum effect observed within six weeks

Detailed Answer:
Dear XXXXXXX
Thanks for follow up query.

Solian takes maximum six weeks to have its intended effect although the some effect may be visible before end of second week.

I hope you had some effect by now although it may take four more weeks to have complete effect.

I hope this assists you in further treatment process.
Thanks and regards.

Above answer was peer-reviewed by : Dr. Vinay Bhardwaj